In this study, an ultra-small superparamagnetic iron oxide (USPIO) contrast agent, Ferumoxytol, was administered to induce an increase in susceptibility for both arteries and veins to help better reveal the cerebral microvasculature. The purpose of this work was to examine the presence of vascular abnormalities and vascular density in MS lesions using high-resolution susceptibility weighted imaging (SWI).
The purpose of this study was to detect cerebral microhemorrhages in military service members with chronic traumatic brain injury by using susceptibility-weighted magnetic resonance (MR) imaging. The longitudinal evolution of microhemorrhages was monitored in a subset of patients by using quantitative susceptibility mapping.
Author(s): E. Mark Haacke, PhD,1y Ann Christine Duhaime, MD,2 Alisa D. Gean, MD,3 Gerard Riedy, MD,4 Max Wintermark, MD,5 Pratik Mukherjee, MD PhD,5,6 David L. Brody, MD,7 Thomas DeGraba, MD,8 Timothy D. Duncan, MD,9 Elie Elovic, MD,10 Robin Hurley, MD,11 Lawrence...
A comparison of magnetic resonance imaging methods to assess multiple sclerosis lesions: Implications for patient characterization and clinical trials design
Author(s): Ewart Mark Haacke, Ph.D; Evanthia Bernitsas; Karthikeyan subramanian; David Utriainen; Vinay K Palutla; Kiran Yerramsetty; Prashanth Kumar; Sean K Sethi; Yongsheng Chen; Zahid Latif; Pavan Jella; sara Gharabaghi; Ying Wang; Xiaomeng Zhang; Robert A Comley;...
Quantitative susceptibility-weighted imaging may be an accurate method for determining stroke hypoperfusion and hypoxia of penumbra
The objective of this study was to quantitatively evaluate the volume of the ischemic penumbra using susceptibility-weighted imaging and mapping (SWIM) of asymmetrical prominent cortical veins (APCVs) in patients with acute ischemic stroke.
Susceptibility-weighted imaging is an increasingly important adjunct in diagnosing a variety of neurologic diseases and provides a powerful tool to depict and help characterize microbleeds, veins, and other sources of susceptibility. But the term SWI is colloquially used to denote high-spatial-resolution susceptibility-enhanced sequences across different MRI vendors and sequences even when phase information is not used.
Author(s): Siamak P Nejad-Davarani 1, Niloufar Zakariaei 1, Yongsheng Chen 2, E Mark Haacke 3 4, Newton J Hurst Jr 1, M Salim Siddiqui 1, Lonni R Schultz 5, James M Snyder 6, Tobias Walbert 6, Carri K Glide-HurstJournal: Medical PhysicsPublished: 2020Read Full...
Imaging the Nigrosome 1 in the substantia nigra using susceptibility weighted imaging and quantitative susceptibility mapping: An application to Parkinson’s disease
The purpose of this study was to create a robust high quality, rapid imaging protocol, determine a slice by slice characterization of the appearance of N1 (the “N1 sign”) and evaluate the loss of the N1 sign in order to differentiate healthy controls (HCs) from patients with PD.
Visualizing the lateral habenula using susceptibility weighted imaging and quantitative susceptibility mapping
The habenulae consist of a pair of small nuclei which bridge the limbic forebrain and midbrain monoaminergic centers. They are implicated in major depressive disorders due to abnormal phasic response when provoked by a conditioned stimulus.
Semi-automatic detection of increased susceptibility in multiple sclerosis white matter lesions imaged with 1.5T MRI
The aims of this study were: 1) to define and validate a semi-automatic method for detecting RoIS in WML from quantitative susceptibility maps (QSM) and susceptibility-weighted imaging (SWI) acquired with a 1.5 T MRI scanner; 2) to assess the prevalence of WML with RoIS and the susceptibility in those areas; and 3) to test the association between RoIS in WML and clinical outcomes.
We hypothesized that cerebral microbleeds (CMBs) in multiple sclerosis (MS) patients will be detected with higher prevalence compared to healthy controls (HC) and that quantitative susceptibility mapping (QSM) will help remove false positives seen in susceptibility weighted imaging (SWI).
Aceruloplasminemia (ACP) is a rare autosomal recessive disorder characterized by intracranial and visceral iron overload. The aim of this study was to provide quantitative iron measurements for each affected brain region in an ACP patient with the potential to do so in all future ACP patients.