In this study, an ultra-small superparamagnetic iron oxide (USPIO) contrast agent, Ferumoxytol, was administered to induce an increase in susceptibility for both arteries and veins to help better reveal the cerebral microvasculature. The purpose of this work was to examine the presence of vascular abnormalities and vascular density in MS lesions using high-resolution susceptibility weighted imaging (SWI).
Quantitative MRI using STrategically Acquired Gradient Echo (STAGE): optimization for 1.5 T scanners and T1 relaxation map validation
The strategically acquired gradient echo (STAGE) protocol, developed for 3T scanners, allows one to derive quantitative maps such as T1, T2*, proton density, and quantitative susceptibility mapping in about 5 min. Our aim was to adapt the STAGE sequences for 1.5T scanners which are still commonly used in clinical practice. Furthermore, the accuracy and repeatability of the STAGE-derived T1 estimate were tested.
Author(s): E. Mark Haacke, PhD,1y Ann Christine Duhaime, MD,2 Alisa D. Gean, MD,3 Gerard Riedy, MD,4 Max Wintermark, MD,5 Pratik Mukherjee, MD PhD,5,6 David L. Brody, MD,7 Thomas DeGraba, MD,8 Timothy D. Duncan, MD,9 Elie Elovic, MD,10 Robin Hurley, MD,11 Lawrence...
Susceptibility-weighted imaging is an increasingly important adjunct in diagnosing a variety of neurologic diseases and provides a powerful tool to depict and help characterize microbleeds, veins, and other sources of susceptibility. But the term SWI is colloquially used to denote high-spatial-resolution susceptibility-enhanced sequences across different MRI vendors and sequences even when phase information is not used.
Author(s): Siamak P Nejad-Davarani 1, Niloufar Zakariaei 1, Yongsheng Chen 2, E Mark Haacke 3 4, Newton J Hurst Jr 1, M Salim Siddiqui 1, Lonni R Schultz 5, James M Snyder 6, Tobias Walbert 6, Carri K Glide-HurstJournal: Medical PhysicsPublished: 2020Read Full...
In this work, we review the basic concepts behind imaging iron using T2, T2*, T2′, phase and quantitative susceptibility mapping in the human brain, liver and heart, followed by the applications of in vivo iron quantification in neurodegenerative diseases, iron tagged cells and ultra-small superparamagnetic iron oxide (USPIO) nanoparticles.
Susceptibility-weighted imaging (SWI) is a method that uses the intrinsic nature of local magnetic fields to enhance image contrast in order to improve the visibility of various susceptibility sources and to facilitate diagnostic interpretation. In this article, we review the basics of SWI, including data acquisition, data reconstruction and post-processing.
Magnetic resonance imaging provides objective biomarkers in the diagnosis of brain injury by detecting brain lesions resulting from trauma. This paper reports on the detection rates of presumed trauma-related pathology using fluid-attenuated inversion recovery (FLAIR) and susceptibility-weighted imaging (SWI) in TBI patients with chronic, persistent symptoms.
Quantitative susceptibility mapping (QSM) is a new technique for quantifying magnetic susceptibility. It has already found various applications in quantifying in vivo iron content, calcifications and changes in venous oxygen saturation. The accuracy of susceptibility mapping is dependent on several factors.
Detection of hemorrhagic and axonal pathology in mild traumatic brain injury using advanced MRI: Implications for neurorehabilitation
There is a need to more accurately diagnose milder traumatic brain injuries with increasing awareness of the high prevalence in both military and civilian populations. The overarching hypothesis of this paper is that newer, advanced MR imaging generates sensitive biomarkers of regional brain injury which allows for correlation with clinical signs and symptoms.