The strategically acquired gradient echo (STAGE) protocol, developed for 3T scanners, allows one to derive quantitative maps such as T1, T2*, proton density, and quantitative susceptibility mapping in about 5 min. Our aim was to adapt the STAGE sequences for 1.5T scanners which are still commonly used in clinical practice. Furthermore, the accuracy and repeatability of the STAGE-derived T1 estimate were tested.
Rapid multicontrast brain imaging on a 0.35T MR-linac
Author(s): Siamak P Nejad-Davarani 1, Niloufar Zakariaei 1, Yongsheng Chen 2, E Mark Haacke 3 4, Newton J Hurst Jr 1, M Salim Siddiqui 1, Lonni R Schultz 5, James M Snyder 6, Tobias Walbert 6, Carri K Glide-HurstJournal: Medical PhysicsPublished: 2020Read Full...
Intracranial iron distribution and quantification in aceruloplasminemia: A case study
Aceruloplasminemia (ACP) is a rare autosomal recessive disorder characterized by intracranial and visceral iron overload. The aim of this study was to provide quantitative iron measurements for each affected brain region in an ACP patient with the potential to do so in all future ACP patients.
STrategically Acquired Gradient Echo (STAGE) imaging, part III: Technical advances and clinical applications of a rapid multi-contrast multi-parametric brain imaging method
One major thrust in radiology today is image standardization with a focus on rapidly acquired quantitative multi-contrast information. In this paper, we discuss the strengths and weaknesses of STAGE, demonstrate its contrast-to-noise (CNR) behavior relative to a large clinical data set and introduce a few new image contrasts derived from STAGE.
Quantifying iron content in magnetic resonance imaging
In this work, we review the basic concepts behind imaging iron using T2, T2*, T2′, phase and quantitative susceptibility mapping in the human brain, liver and heart, followed by the applications of in vivo iron quantification in neurodegenerative diseases, iron tagged cells and ultra-small superparamagnetic iron oxide (USPIO) nanoparticles.
Regional High Iron in the Substantia Nigra Differentiates Parkinson’s Disease Patients From Healthy Controls
Iron is important in the pathophysiology of Parkinson’s disease (PD) specifically related to degeneration of the substantia nigra (SN). The goal of this work was to use quantitative susceptibility mapping (QSM) and R2∗ to quantify both global and regional brain iron in PD patients and healthy controls (HC) to ascertain if regional changes correlate with clinical conditions and can be used to discriminate patients from controls.
STrategically Acquired Gradient Echo (STAGE) imaging, part I: Creating enhanced T1 contrast and standardized susceptibility weighted imaging and quantitative susceptibility mapping
The purpose of this study was to provide whole brain grey matter (GM) to white matter (WM) contrast enhanced T1W (T1WE) images, multi-echo quantitative susceptibility mapping (QSM), proton density (PD) weighted images, T1 maps, PD maps, susceptibility weighted imaging (SWI), and R2* maps with minimal misregistration in scanning times < 5 min.
Susceptibility Weighted Imaging and Quantitative Susceptibility Mapping of the Cerebral Vasculature Using Ferumoxytol
The purpose of this study was to demonstrate the potential of imaging cerebral arteries and veins with ferumoxytol using susceptibility weighted imaging (SWI) and quantitative susceptibility mapping (QSM).