In this study, an ultra-small superparamagnetic iron oxide (USPIO) contrast agent, Ferumoxytol, was administered to induce an increase in susceptibility for both arteries and veins to help better reveal the cerebral microvasculature. The purpose of this work was to examine the presence of vascular abnormalities and vascular density in MS lesions using high-resolution susceptibility weighted imaging (SWI).
Imaging of the Spinal Cord in Multiple Sclerosis: Past, Present, Future
Author(s): Yongsheng Chen 1 , Ewart Mark Haacke 1,2 and Evanthia BernitsasJournal: Brain SciencesPublished: 2020Read Full Paper: https://www.mdpi.com/2076-3425/10/11/857 Abstract Spinal cord imaging in multiple sclerosis (MS) plays a significant role in diagnosing and...
A comparison of magnetic resonance imaging methods to assess multiple sclerosis lesions: Implications for patient characterization and clinical trials design
Author(s): Ewart Mark Haacke, Ph.D; Evanthia Bernitsas; Karthikeyan subramanian; David Utriainen; Vinay K Palutla; Kiran Yerramsetty; Prashanth Kumar; Sean K Sethi; Yongsheng Chen; Zahid Latif; Pavan Jella; sara Gharabaghi; Ying Wang; Xiaomeng Zhang; Robert A Comley;...
Semi-automatic detection of increased susceptibility in multiple sclerosis white matter lesions imaged with 1.5T MRI
The aims of this study were: 1) to define and validate a semi-automatic method for detecting RoIS in WML from quantitative susceptibility maps (QSM) and susceptibility-weighted imaging (SWI) acquired with a 1.5 T MRI scanner; 2) to assess the prevalence of WML with RoIS and the susceptibility in those areas; and 3) to test the association between RoIS in WML and clinical outcomes.
Longitudinal Magnetic Resonance Imaging of Cerebral Microbleeds in Multiple Sclerosis Patients
We hypothesized that cerebral microbleeds (CMBs) in multiple sclerosis (MS) patients will be detected with higher prevalence compared to healthy controls (HC) and that quantitative susceptibility mapping (QSM) will help remove false positives seen in susceptibility weighted imaging (SWI).
Multiple Sclerosis Use Cases
The STAGE protocol helps to provide brain images which help differentiate Multiple Sclerosis lesion properties. The susceptibility-based STAGE outputs help differentiate normal appearing white matter from those which may have become demyelinated…
Cerebral Microbleeds in Multiple Sclerosis Evaluated on Susceptibility-weighted Images and Quantitative Susceptibility Maps: A Case-Control Study
The purpose of this study was to assess cerebral microbleed (CMB) prevalence in patients with multiple sclerosis (MS) and clinically isolated syndrome (CIS) and associations with clinical outcomes.
Breakthroughs in Imaging Neurovascular Diseases
Google Tech Talk September 16, 2010 Breakthroughs in Imaging Neurovascular Diseases such as Multiple Sclerosis: Technical Aspects, Clinical Ramifications, and Understanding the Etiology of the Disease. Presented by Dr. E....