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Plaque Susceptibility edit

Plaque characteristics of middle cerebral artery assessed using strategically acquired gradient echo (STAGE) and vessel wall MR contribute to misery downstream perfusion in patients with intracranial atherosclerosis

By: Karen Holzberger, President & CEO of SpinTech MRI

Author(s): Tong Zhang1,2 & Ruowei Tang1,2 & Song Liu1,2 & Chao Chai1,2 & Yongsheng Chen3,4 & E. Mark Haacke3,4 & Shuang Xia2
Journal: European Radiology
Published: 2020
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Plaque Susceptibility


To assess plaque vulnerability of the middle cerebral artery (MCA) using strategically acquired gradient echo (STAGE) versus high-resolution vessel wall MRI (hr-vwMRI), and explore the relationship between plaque characteristics and misery downstream perfusion.


Ninety-one patients with single MCA atherosclerotic plaques underwent STAGE and hr-vwMRI were categorized into a group with misery perfusion and a group without based on the Alberta Stroke Program Early CT score (MTT-ASPECTS) with a threshold of 6. Plaque characteristics including inner lumen area (IWA), susceptibility, presence of hyperintensity within plaque (HIP), surface irregularity, stenosis degree, remodeling index, lipid ratio, and enhancement grade were compared between the two groups.

The vulnerability of each plaque was retrospectively assessed on both STAGE and hr-vwMRI according to the combination of plaque features. Logistic regression analysis and ROC curve were performed to evaluate the effect of plaque characteristics on the presence of misery perfusion.


Taking hr-vwMRI as the reference, STAGE showed good efficiency in detecting vulnerable plaques. Patients with misery perfusion had less IWA, higher stenosis degree, more irregular surface and HIP, higher enhancement grade, and susceptibility (p < 0.01 for all). Higher susceptibility and stenosis degree were independent predictors for the occurrence of misery perfusion (p = 0.025, p = 0.048). The AUC was 0.900 for the combination of the two variables.


STAGE shows good efficiency to assess MCA plaque vulnerability versus hr-vwMRI. Plaque susceptibility evaluated using STAGE provides incremental value to predict misery perfusion combined with hr-vwMRI plaque features.

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